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A first-choice combined oral contraceptive influences general well-being in healthy women: a double-blind, randomized, placebo-controlled trial

Artikel i vetenskaplig tidskrift
Författare N. Zethraeus
A. Dreber
Eva Ranehill
L. Blomberg
F. Labrie
Bo von Schoultz
M. Johannesson
A. L. Hirschberg
Publicerad i Fertility and Sterility
Volym 107
Nummer/häfte 5
Sidor 1238-1245
ISSN 0015-0282
Publiceringsår 2017
Publicerad vid Institutionen för nationalekonomi med statistik
Sidor 1238-1245
Språk English
Länkar https://doi.org/10.1016/j.fertnster...
Ämnesord Depression, oral contraceptives, quality of life, randomized clinical trial, well-being, sexual function, mood, symptoms, allopregnanolone, discontinuation, levonorgestrel, testosterone, drospirenone, improvement, depression, Obstetrics & Gynecology, Reproductive Biology
Ämneskategorier Obstetrik och kvinnosjukdomar

Sammanfattning

Objective: To determine whether there is a causal effect of oral contraceptive (OC) treatment on general well-being and depressed mood in healthy women. Patient(s): Three hundred and forty healthy women aged 18-35 years randomized to treatment, of whom 332 completed the data collection at follow-up evaluation. Intervention(s): A combined OC (150 mg levonorgestrel and 30 mu g ethinylestradiol) or placebo for 3 months of treatment. Main Outcome Measure(s): Primary outcome measures: global score of Psychological General Well-Being Index (PGWBI) and the Beck Depression Inventory (BDI); secondary outcome measures: six separate dimensions of the PGWBI. Result(s): The OC treatment statistically significantly decreased general well-being compared with placebo -4.12 (95% CI, -7.18 to -1.06). Furthermore, OC decreased the following PGWBI dimensions compared with placebo: positive well-being -3.90 (95% CI, -7.78 to -0.01), self-control - 6.63 (95% CI, -11.20 to -2.06), and vitality -6.84 (95% CI, -10.80 to -2.88). The effect of OC on depressive symptoms and on the PGWBI dimension depressed mood were not statistically significant. Conclusion(s): This study demonstrates a statistically significant reduction in general well-being by a first-choice OC in comparison with placebo in healthy women. We found no statistically significant effects on depressive symptoms. A reduction in general well-being should be of clinical importance. (C) 2017 by American Society for Reproductive Medicine.

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