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Living Donor Uterus Transplantation: A Single Center's Observations and Lessons Learned From Early Setbacks to Technical Success.

Artikel i vetenskaplig tidskrift
Författare G Testa
E C Koon
L Johannesson
G J McKenna
T Anthony
G B Klintmalm
R T Gunby
A M Warren
J M Putman
G dePrisco
J M Mitchell
K Wallis
Michael Olausson
Publicerad i American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons
Volym 385
Sidor 1-10
ISSN 1600-6143
Publiceringsår 2017
Publicerad vid Institutionen för kliniska vetenskaper, sektionen för kirurgi och kirurgisk gastroforskning, Avdelningen för plastikkirurgi
Sidor 1-10
Språk en
Länkar dx.doi.org/10.1111/ajt.14326
www.ncbi.nlm.nih.gov/entrez/query.f...
Ämneskategorier Transplantationskirurgi

Sammanfattning

Uterus transplantation is a vascularized composite allograft transplantation. It allows women who do not have a uterus to become pregnant and deliver a baby. In this paper, we analyze the first five cases of living donor uterus transplantation performed in the United States. The first three recipients lost their uterus grafts at days 14, 12, and 6, respectively, after transplant. Vascular complications, related to both inflow and outflow problems, were identified as the primary reason for the graft losses. Two recipients, at 6 and 3 mo, respectively, after transplant, have functioning grafts with regular menstrual cycles. Ultimate success will be claimed only after a live birth. This paper is an in-depth analysis of evaluation, surgical technique, and follow-up of these five living donor uterus transplants. The lessons learned were instrumental in allowing us to evolve from failure to technical and functional success. We aim to share our conclusions and build on knowledge in the evolving field of uterus transplantation.

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