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Study on release of naproxen and metformin encapsulated in biopolymer-inorganic mesoporous matrices as controlled drug-delivery systems

Artikel i vetenskaplig tidskrift
Författare M. Ghazaie
Payam Ghiaci
M. Ghiaci
Publicerad i Microporous and Mesoporous Materials
Volym 244
Sidor 291-300
ISSN 1387-1811
Publiceringsår 2017
Publicerad vid Institutionen för kemi och molekylärbiologi
Sidor 291-300
Språk English Nger r , 1980 , chemical engineering communications , v6 , p1
Länkar dx.doi.org/10.1016/j.micromeso.2016...
Ämnesord Porous coating, Chitosan, Sol-gel method, Zirconium(IV) propoxide, Tetraethyl orthosilicate, N-, CHITOSAN, NANOPARTICLES, TUMORS, GEL
Ämneskategorier Kompositmaterial och -teknik

Sammanfattning

In this study, a new methodology was applied for controlling the release of different drugs by encapsulating them in organic-inorganic hybrids via sol-gel technique. The assembled organic-inorganic hybrids had diverse BET surface area, porosity, and high heat resistance. The synthesized organic-inorganic hybrids were based on zirconium(IV) propoxide, and tetraethyl orthosilicate as precursor of inorganic network, and chitosan or N-triethylchitosan as organic or biopolymer components. In these hybrid composites, drug and biopolymer were coated with a mesoporous inorganic material. FT-IR, FE-SEM, DSC, BET, XRD techniques, and Zeta potential analysis used for investigating the formation of metformin/ chitosan@ZrO2 and sodium naproxen/N-triethylchitosan@SiO2 hybrid composites. Then for investigating the role of sol-gel process, the release of metformin and sodium naproxen in the prepared hybrid composites was investigated as model drugs. Compare to drugibiopolymer composite, incorporation of ZrO2 or SiO2 coating enhanced the drug entrapment appreciably, and naturally reduced the rate of drug release. For example, the metformin/chitosan composite without ZrO2 coating released the whole drug in less than10 h in pH 7.4 when the composite coated with ZrO2 released the entrapped drug after 25 h. (C) 2016 Elsevier Inc. All rights reserved.

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