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Attenuated Low-Grade Inflammation Following Long-Term Dietary Intervention in Postmenopausal Women with Obesity

Artikel i vetenskaplig tidskrift
Författare C. Blomquist
M. Alvehus
J. Buren
M. Ryberg
Christel Larsson
B. Lindahl
C. Mellberg
I. Soderstrom
E. Chorell
T. Olsson
Publicerad i Obesity
Volym 25
Nummer/häfte 5
Sidor 892-900
ISSN 1930-7381
Publiceringsår 2017
Publicerad vid Institutionen för kost- och idrottsvetenskap
Sidor 892-900
Språk English
Länkar doi.org/10.1002/oby.21815
Ämnesord paleolithic-type diet, adipose-tissue, weight-loss, insulin-resistance, metabolic syndrome, randomized-trial, glucose-tolerance, mononuclear-cells, messenger-rna, life-style, Endocrinology & Metabolism, Nutrition & Dietetics
Ämneskategorier Näringslära, Endokrinologi och diabetes

Sammanfattning

ObjectiveAbdominal fat accumulation after menopause is associated with low-grade inflammation and increased risk of metabolic disorders. Effective long-term lifestyle treatment is therefore needed. MethodsSeventy healthy postmenopausal women (age 605.6 years) with BMI 32.55.5 were randomized to a Paleolithic-type diet (PD) or a prudent control diet (CD) for 24 months. Blood samples and fat biopsies were collected at baseline, 6 months, and 24 months to analyze inflammation-related parameters. ResultsAndroid fat decreased significantly more in the PD group (P=0.009) during the first 6 months with weight maintenance at 24 months in both groups. Long-term significant effects (P<0.001) on adipose gene expression were found for toll-like receptor 4 (decreased at 24 months) and macrophage migration inhibitory factor (increased at 24 months) in both groups. Serum interleukin 6 (IL-6) and tumor necrosis factor levels were decreased at 24 months in both groups (P<0.001) with a significant diet-by-time interaction for serum IL-6 (P=0.022). High-sensitivity C-reactive protein was decreased in the PD group at 24 months (P=0.001). ConclusionsA reduction of abdominal obesity in postmenopausal women is linked to specific changes in inflammation-related adipose gene expression.

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