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Lower prostate cancer risk in Swedish men with the androgen receptor E213 A-allele

Artikel i vetenskaplig tidskrift
Författare M. B. Holgersson
Y. Ruhayel
M. Karlsson
A. Giwercman
A. Bjartell
Claes Ohlsson
Dan Mellström
O. Ljunggren
Mohammad-Ali Haghsheno
Jan-Erik Damber
Y. L. Giwercman
Publicerad i Cancer Causes & Control
Volym 28
Nummer/häfte 3
Sidor 227-233
ISSN 0957-5243
Publiceringsår 2017
Publicerad vid Institutionen för kliniska vetenskaper, sektionen för onkologi, radiofysik, radiologi och urologi, Avdelningen för urologi
Sahlgrenska Cancer Center
Centre for Bone and Arthritis Research
Institutionen för medicin, avdelningen för invärtesmedicin och klinisk nutrition
Sidor 227-233
Språk English
Länkar doi.org/10.1007/s10552-017-0859-1
Ämnesord Androgen receptor, Prostate cancer, Genetic variants, male pattern baldness, repeat polymorphism, genetic-variation, alopecia, Oncology, Public, Environmental & Occupational Health
Ämneskategorier Miljömedicin och yrkesmedicin, Cancer och onkologi

Sammanfattning

In a previous population-based study on 3369 European men with self-reported prostate cancer (PCa), it was shown that androgen receptor (AR) haplotype designated H2 was associated with high levels of serum PSA (prostate-specific antigen) concentration, and, at the same time, with low risk for PCa. The aim of this study was to replicate this finding in other cohorts, with registry-based cancer diagnosis. Using data from two population-based cohorts; the Malmo Diet and Cancer Study (MDCS, n = 12,121) and the Swedish Osteoporotic fractures in men study (MrOS, n = 1,120), 628 men with PCa and 1,374 controls were identified and genotyped. PCa data were collected from the Swedish national cancer registry. PCa odds ratios (ORs) and 95% confidence intervals (CIs) were calculated for carriers of the particular AR haplotype, tagged by the rs6624304 T-allele. The 15% of men who were carriers of the AR haplotype H2 had approximately one-third lower risk for PCa diagnosis compared to those with the most common H1 variant (OR 0.65; 95% CI 0.45-0.94; p = 0.021). The same trend, although not statistically significant (OR 0.75; 95% CI 0.47-1.24; p = 0.275), was observed in MrOS Sweden. When both cohorts were merged, an even more significant result was observed (OR 0.68; 95% CI 0.51-0.90; p = 0.008). Swedish men with the variant AR haplotype H2, tagged by rs6624304, have significantly lower risk of PCa compared to those with the more common variant.

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