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The Neurobiological Impact of Ghrelin Suppression after Oesophagectomy

Artikel i vetenskaplig tidskrift
Författare C. F. Murphy
Carel W le Roux
Publicerad i International Journal of Molecular Sciences
Volym 18
Nummer/häfte 1
ISSN 1422-0067
Publiceringsår 2017
Publicerad vid Institutionen för kliniska vetenskaper, sektionen för kirurgi och kirurgisk gastroforskning, Avdelningen för gastrokirurgisk forskning och utbildning
Språk English
Länkar doi.org/10.3390/ijms18010035
Ämnesord ghrelin, ghrelin suppression, GHS-R1A, oesophageal carcinoma, appetite, anticipatory feeding, reward-induced feeding, oesophagectomy, hormone secretagogue receptor, gastric bypass-surgery, brown, adipose-tissue, stimulates locomotor-activity, des-acyl ghrelin, body-weight loss, cancer cachexia, messenger-rna, food-intake, neoadjuvant chemoradiotherapy, Biochemistry & Molecular Biology, Chemistry
Ämneskategorier Gastroenterologi

Sammanfattning

Ghrelin, discovered in 1999, is a 28-amino-acid hormone, best recognized as a stimulator of growth hormone secretion, but with pleiotropic functions in the area of energy homeostasis, such as appetite stimulation and energy expenditure regulation. As the intrinsic ligand of the growth hormone secretagogue receptor (GHS-R), ghrelin appears to have a broad array of effects, but its primary role is still an area of debate. Produced mainly from oxyntic glands in the stomach, but with a multitude of extra-metabolic roles, ghrelin is implicated in complex neurobiological processes. Comprehensive studies within the areas of obesity and metabolic surgery have clarified the mechanism of these operations. As a stimulator of growth hormone (GH), and an apparent inducer of positive energy balance, other areas of interest include its impact on carcinogenesis and tumour proliferation and its role in the cancer cachexia syndrome. This has led several authors to study the hormone in the cancer setting. Ghrelin levels are acutely reduced following an oesophagectomy, a primary treatment modality for oesophageal cancer. We sought to investigate the nature of this postoperative ghrelin suppression, and its neurobiological implications.

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