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Antecedents and neuroimaging patterns in cerebral palsy with epilepsy and cognitive impairment: a population-based study in children born at term.

Artikel i vetenskaplig tidskrift
Författare Kristina Ahlin
Bo Jacobsson
Staffan Nilsson
Kate Himmelmann
Publicerad i Acta obstetricia et gynecologica Scandinavica
Volym 96
Nummer/häfte 7
Sidor 828–836
ISSN 1600-0412
Publiceringsår 2017
Publicerad vid Institutionen för matematiska vetenskaper
Institutionen för kliniska vetenskaper, sektionen för kvinnors och barns hälsa, Avdelningen för obstetrik och gynekologi
Institutionen för kliniska vetenskaper, sektionen för kvinnors och barns hälsa, Avdelningen för pediatrik
Sidor 828–836
Språk en
Länkar dx.doi.org/10.1111/aogs.13128
www.ncbi.nlm.nih.gov/entrez/query.f...
Ämneskategorier Klinisk medicin

Sammanfattning

Antecedents of accompanying impairments in cerebral palsy (CP) and their relation to neuroimaging patterns need to be explored.A population-based study of 309 children with CP born at term in 1983-1994. Pre-, intra- and postpartum variables previously studied as antecedents of CP type and motor severity were analysed in children with CP and cognitive impairment and/or epilepsy, and in children with CP without these accompanying impairments. Neuroimaging patterns and their relation to identified antecedents were analysed. Data were retrieved from the CP register of western Sweden, obstetric and neonatal records.Children with CP and accompanying impairments more often had low birth weight (kg) (OR 0.5 95% CI; 0.3-0.8), brain maldevelopment known at birth (p=0.007, OR ∞) and neonatal infection (OR 5.4 (1.04-28.4). Moreover, neuroimaging patterns of maldevelopment (OR 7.2 95% CI; 2.9-17.2), cortical/subcortical lesions (OR 5.3 95% CI; 2.3-12.2) and basal ganglia lesions (OR 7.6 95% CI; 1.4-41.3) were more common, wheras white matter injury was found significantly less often (OR 0.2 95% CI; 0.1-0.5). In most children with maldevelopment, the intra- and postpartum period was uneventful (p<0.05). Cerebral maldevelopment was associated with prepartum antecedents,while subcortical/cortical and basal ganglia lesions were associated with intra- and postpartum antecedents.No additional factor other than those related to motor impairment was associated with epilepsy and cognitive impairment in CP. Timing of antecedents deemed important for the development of CP with accompanying impairments were supported by neuroimaging patterns. This article is protected by copyright. All rights reserved.

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