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Relationships between Stress Granules, Oxidative Stress, and Neurodegenerative Diseases

Forskningsöversiktsartikel
Författare Lihua Chen
Beidong Liu
Publicerad i Oxidative Medicine and Cellular Longevity
Volym 2017
ISSN 1942-0900
Publiceringsår 2017
Publicerad vid Institutionen för kemi och molekylärbiologi
Språk English
Länkar https://doi.org/10.1155/2017/180959...
Ämnesord amyotrophic-lateral-sclerosis, polyadenylated messenger-rna, dna-binding, protein, p-bodies, translational repression, saccharomyces-cerevisiae, alzheimers-disease, parkinsons-disease, hydrogen-peroxide, heat-stress, Cell Biology
Ämneskategorier Kemi, Biologiska vetenskaper

Sammanfattning

Cytoplasmic stress granules (SGs) are critical for facilitating stress responses and for preventing the accumulation of misfolded proteins. SGs, however, have been linked to the pathogenesis of neurodegenerative diseases, in part because SGs share many components with neuronal granules. Oxidative stress is one of the conditions that induce SG formation. SGs regulate redox levels, and SG formation in turn is differently regulated by various types of oxidative stress. These associations and other evidences suggest that SG formation contributes to the development of neurodegenerative diseases. In this paper, we review the regulation of SG formation/assembly and discuss the interactions between oxidative stress and SG formation. We then discuss the links between SGs and neurodegenerative diseases and the current therapeutic approaches for neurodegenerative diseases that target SGs.

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