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High androgen levels protect against hypothyroidism

Artikel i vetenskaplig tidskrift
Författare Johanna Schmidt
Eva Dahlgren
Inger Bryman
K. Berntorp
Penelope Trimpou
Lars Wilhelmsen
Kerstin Landin-Wilhelmsen
Publicerad i Acta Obstetricia Et Gynecologica Scandinavica
Volym 96
Nummer/häfte 1
Sidor 39-46
ISSN 0001-6349
Publiceringsår 2017
Publicerad vid Institutionen för medicin
Institutionen för medicin, avdelningen för invärtesmedicin och klinisk nutrition
Institutionen för kliniska vetenskaper, sektionen för kvinnors och barns hälsa, Avdelningen för obstetrik och gynekologi
Sidor 39-46
Språk English
Länkar dx.doi.org/10.1111/aogs.13054
Ämnesord Androgens, hypothyroidism, polycystic ovary syndrome, Turner syndrome, polycystic-ovary-syndrome, term-follow-up, subclinical hypothyroidism, cardiovascular-disease, turner-syndrome, risk-factors, postmenopausal, women, thyroid-dysfunction, age, autoimmunity, Obstetrics & Gynecology, kahashi k, 1994, human reproduction, v9, p2255, aub jj, 1992, american journal of medicine, v92, p631, iovato l, 1993, journal of endocrinological investigation, v16, p384
Ämneskategorier Klinisk medicin

Sammanfattning

IntroductionHypothyroidism is a common disorder, appearing mainly in women although less frequently found in women with polycystic ovary syndrome (PCOS). The objective was to test the hypothesis that hyperandrogenism might protect against hypothyroidism. Material and methodsThe data from three prospective follow-up studies (up to 21years) and one register study were compared: women with PCOS (Rotterdam criteria), n=25, women with Turner syndrome, n=217, a random population sample of women, n=315, and men, n=95 (the WHO MONICA study). Findings were to be verified or rejected in all females, n=553 716, from the same region. The proportion of hypothyroidism was calculated and thyroid peroxidase antibodies (TPO) in serum were measured. ResultsHypothyroidism at >50years of age was found in 8% of women with PCOS, 4% in men (PCOS vs. men; ns), 43% of women with Turner syndrome, irrespective of karyotype (p<0.001 vs. PCOS), and in 17% of postmenopausal women in the population (p<0.01 vs. PCOS). Elevated TPO were similar in PCOS and women and men in the population but higher in Turner syndrome. Hypothyroidism increased with age in all groups except PCOS women and men. In the register study, hypothyroidism was less common in women with PCOS >25years (5.5%) than in women without PCOS (6.8%) from the same region (p<0.01). ConclusionsHypothyroidism was less frequently seen in women with PCOS and in men compared with women in the general population and among women with Turner syndrome. This was not explained by altered autoimmunity or the Y-chromosome. Androgens seem to protect against hypothyroidism.

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