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Live donors of the initial observational study of uterus transplantation-Psychological and medical follow up until 1 year after surgery in the 9 cases.

Artikel i vetenskaplig tidskrift
Författare Niclas Kvarnström
Stina Järvholm
Liza Johannesson
Pernilla Dahm-Kähler
Michael Olausson
Mats Brännström
Publicerad i Transplantation
Volym 101
Nummer/häfte 3
Sidor 664-670
ISSN 1534-6080
Publiceringsår 2017
Publicerad vid Institutionen för kliniska vetenskaper, sektionen för kirurgi och kirurgisk gastroforskning, Avdelningen för kirurgi
Institutionen för kliniska vetenskaper, sektionen för kvinnors och barns hälsa, Avdelningen för obstetrik och gynekologi
Sidor 664-670
Språk en
Länkar dx.doi.org/10.1097/TP.0000000000001...
www.ncbi.nlm.nih.gov/entrez/query.f...
Ämneskategorier Reproduktionsmedicin och gynekologi

Sammanfattning

The first prospective observational study of uterus transplantation was initiated in 2013 with live donation to 9 women with absolute uterine factor infertility. We explored the medical complications and psychosocial wellbeing of the donors during the first postoperative year.Complications were registered and graded according to the Clavien-Dindo (C-D) classification. Symptoms related to the surgery were registered. Data on length of hospital stay, sick leave, socioeconomic parameters and life events were obtained. Psychological evaluations (PGWB, DAS, HADS, SF-36) questionnaires focusing on quality-of-life, mood, and relationship, were conducted at inclusion and at 3, 6 and 12 months after uterus donation.One major surgical complication (C-D IIIb) occurred. A ureteric-vaginal fistula developed 2 weeks after uterus procurement. The fistula was surgically repaired. Two self-reported and transient complications (C-D I) were noted (nocturia, meralgia paresthetica). Hospital stays of all donors were 6 days and median sick leave was 56 days (range 14-132). At inclusion, median scores exceeded the normative values of the Swedish population in PGWB and DAS. Anxiety (HADS-A) was detected preoperatively in 1 donor. Two donors exceeded 10-point declines in SF-36 summary scores and increased their HADS scores by 6 points during the observation period. All donors returned to their predonation levels of physical health.The results support that it is feasible to retrieve a uterus safely from a live donor. Further studies are needed to better evaluate the method.

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