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Design-corrected variation by centre in mortality reduction in the ERSPC randomised prostate cancer screening trial.

Artikel i vetenskaplig tidskrift
Författare Matti Hakama
Sue M Moss
Ulf-Hakan Stenman
Monique J Roobol
Marco Zappa
Sigrid Carlsson
Marco Randazzo
Vera Nelen
Jonas Hugosson
Publicerad i Journal of medical screening
Volym 24
Nummer/häfte 2
Sidor 98-103
ISSN 1475-5793
Publiceringsår 2017
Publicerad vid Institutionen för kliniska vetenskaper, sektionen för onkologi, radiofysik, radiologi och urologi, Avdelningen för urologi
Sidor 98-103
Språk en
Länkar dx.doi.org/10.1177/0969141316652174
www.ncbi.nlm.nih.gov/entrez/query.f...
Ämneskategorier Urologi och andrologi, Urologi och njurmedicin, Cancer och onkologi

Sammanfattning

To calculate design-corrected estimates of the effect of screening on prostate cancer mortality by centre in the European Randomised Study of Screening for Prostate Cancer (ERSPC).The ERSPC has shown a 21% reduction in prostate cancer mortality in men invited to screening with follow-up truncated at 13 years. Centres either used pre-consent randomisation (effectiveness design) or post-consent randomisation (efficacy design).In six centres (three effectiveness design, three efficacy design) with follow-up until the end of 2010, or maximum 13 years, the effect of screening was estimated as both effectiveness (mortality reduction in the target population) and efficacy (reduction in those actually screened).The overall crude prostate cancer mortality risk ratio in the intervention arm vs control arm for the six centres was 0.79 ranging from a 14% increase to a 38% reduction. The risk ratio was 0.85 in centres with effectiveness design and 0.73 in those with efficacy design. After correcting for design, overall efficacy was 27%, 24% in pre-consent and 29% in post-consent centres, ranging between a 12% increase and a 52% reduction.The estimated overall effect of screening in attenders (efficacy) was a 27% reduction in prostate cancer mortality at 13 years' follow-up. The variation in efficacy between centres was greater than the range in risk ratio without correction for design. The centre-specific variation in the mortality reduction could not be accounted for by the randomisation method.

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