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T-Tau is Associated with Objective Memory Decline over Two Years in Persons Seeking Help for Subjective Cognitive Decline: A Report from the Gothenburg-Oslo MCI Study

Artikel i vetenskaplig tidskrift
Författare E. Hessen
Arto Nordlund
Jacob Stålhammar
Marie Eckerström
Maria Bjerke
Carl Eckerström
Mattias Göthlin
T. Fladby
I. Reinvang
Anders Wallin
Publicerad i Journal of Alzheimer's Disease
Volym 47
Nummer/häfte 3
Sidor 619-628
ISSN 1387-2877
Publiceringsår 2015
Publicerad vid Institutionen för neurovetenskap och fysiologi, sektionen för psykiatri och neurokemi
Sidor 619-628
Språk en
Länkar dx.doi.org/10.3233/JAD-150109
Ämnesord Cerebrospinal fluid biomarkers , early amnestic MCI , memory decline , mild cognitive impairment (MCI) , pre-clinical AD , pre-clinical dementia , subjective cognitive decline , T-tau
Ämneskategorier Neurovetenskap

Sammanfattning

© 2015 - IOS Press and the authors. All rights reserved. Background: There is a need to find very early markers for pre-clinical Alzheimer's disease as interventions early in the disease process are thought to be most effective. Objective: The present study aimed to address the potential relation between cerebrospinal fluid (CSF) biomarkers and reduced cognitive function in a relatively young cohort of memory clinic patients with subjective cognitive decline. Methods: 122 patients (mean age 63 years) with subjective cognitive decline were recruited from two university memory clinics and followed for two years. Results: The main finding was that the subgroup with objective memory decline during the study period had significantly higher T-tau at baseline than the group with improved memory. Baseline CSF variables showed a trend toward more pathological values in the patients with memory decline compared to those who improved or remained stable.Tthe baseline memory score of those who declined was significantly better than the baseline score of those who improved over two years.Tthe general trend for the whole group was improved memory and executive test scores.Tthere were no differences in cognitive scores based on CSF quartiles at baseline, nor were there differences in cognitive outcome for patients with early amnestic mild cognitive impairment versus average cognitive function at baseline. Conclusions: The main finding that T-tau rather than amyloid-β was associated with memory decline do not support the prevailing opinion about the chain of events assumed to take place in Alzheimer's disease. In addition, memory decline was not associated with poor baseline memory score. Thus, a memory cut-off indicating low baseline memory would not would have identified the declining group.

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