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Study on montmorillonite/insulin/TiO2 hybrid nanocomposite as a new oral drug-delivery system

Journal article
Authors Y. Kamari
Payam Ghiaci
M. Ghiaci
Published in Materials Science and Engineering C
Volume 75
Pages 822-828
ISSN 09284931 (ISSN)
Publication year 2017
Published at Department of Chemistry and Molecular Biology
Pages 822-828
Language English
Links dx.doi.org/10.1016/j.msec.2017.02.1...
Keywords Hybrid nanocomposite, Insulin, Intercalation, Montmorillonite, Oral drug delivery, TiO2, Clay minerals, Coatings, Deionized water, Titanium dioxide, Drug entrapment, Hybrid nanocomposites, Montmorillonite nanocomposites, Oral drug delivery system, Porous coatings, Titanium butoxide, Zeta potential analysis, Nanocomposites
Subject categories Pharmaceutical Sciences, Pharmacology

Abstract

This study was conducted in two main stages. In the first stage, drug-loaded montmorillonite nanocomposites were prepared by intercalation of insulin into the montmorillonite layers in acidic deionized (DI) water. In the second stage, to increase the release of insulin from the prepared nanocomposites they were coated with TiO2, an inorganic porous coating, by using titanium (IV) butoxide, as precursor. The prepared nanocomposites were characterized by FT-IR, XRD, FE-SEM, BET, DLS and Zeta potential analysis. After investigating the release behaviour of the nanocomposites by UV–Vis absorbance technique, the results revealed that incorporation of porous TiO2 coating increased the drug entrapment noticeably, and decreased the amount of drug release, so that nanocomposites without and with TiO2 coating released the drug after 60 min and 22 h in pH 7.4, respectively. These results could be used in converting the insulin utilization from injection to oral. © 2017 Elsevier B.V.

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