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Uterus transplantation: current state and future perspectives

Journal article
Authors Mats Brännström
Pernilla Dahm-Kahler
Published in Journal of Endometriosis and Pelvic Pain Disorders
Volume 9
Issue 1
Pages 2-8
ISSN 2284-0265
Publication year 2017
Published at Institute of Clinical Sciences, Section for the Health of Women and Children, Department of Obstetrics and Gynecology
Pages 2-8
Language English
Links 10.5301/je.5000269
Keywords Human, Infertility, Transplantation, Uterus, early reperfusion events, surgical technique, uterine transplantation, vascular anastomosis, multiorgan donor, cyclosporine-a, rat model, pregnancy, mouse, autotransplantation
Subject categories Obstetrics, Gynecology and Reproductive Medicine

Abstract

Absolute uterine factor infertility (AUFI) has traditionally been regarded as untreatable. Gestational surrogacy (GS) is not permitted in most countries and societies in the world due to ethical, religious or legal reasons. The interest in uterus transplantation (UTx) as a treatment for AUFI started in the 1960s and, after some disappointing results, raised again in the new century, when our and other groups obtained live off-spring after UTx in the mouse, and here we review extensively the results of animal research. In September 2014, the first baby was born after human UTx and this proof-of-concept of UTx as an infertility treatment has been followed by several more births. All cases described in the literature are also reviewed. The overall evidence suggests that the clinical introduction of UTx as the first available treatment for AUFI has been successful. However, UTx will stay at experimental stage for several years whilst optimizing the procedure and ensuring its safety from a medical and psychological perspective.

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