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Cohort Profile: The INTERGENE Study.

Journal article
Authors Kirsten Mehlig
Christina Berg
Lena Björck
Fredrik Nyberg
Anna-Carin Olin
Annika Rosengren
Elisabeth Strandhagen
Kjell Torén
Dag Thelle
Lauren Lissner
Published in International journal of epidemiology
ISSN 1464-3685
Publication year 2017
Published at Institute of Medicine, Department of Public Health and Community Medicine
Institute of Medicine, Department of Public Health and Community Medicine, Section of Occupational and environmental medicine
Institute of Medicine, Department of Public Health and Community Medicine, Public Health Epidemiology Unit
Institute of Health and Care Sciences
Department of Food and Nutrition, and Sport Science
Institute of Medicine, Department of Molecular and Clinical Medicine
Language en
Links dx.doi.org/10.1093/ije/dyw332
www.ncbi.nlm.nih.gov/entrez/query.f...
Subject categories Epidemiology, Public health science, Community medicine

Abstract

In 2001, the INTERGENE research programme established a population-based cohort of 3614 adults living in south-western Sweden. The aim was to assess environmental, lifestyle and hereditary risk factors for cardio-metabolic and respiratory diseases, and to document secular changes in many of these characteristics. Because the focus is on coronary heart disease (CHD), the population cohort was complemented with 618 patients with acute or chronic CHD who were sampled during the examination period for the cohort (2001–04), following the same protocol. More than 800 variables describe lifestyle and socio-demographic characteristics from questionnaires, anthropometric characteristics from physical examinations, and biomarkers from blood sampled during the examination. Additional blood samples and extracted DNA are stored in biobanks. Data from the case-control study of CHD were used to investigate associations between common risk factors (overweight, smoking, alcohol consumption, sedentary behaviour) and different candidate genes with respect to CHD, and explore interactions. In addition, a biomarker for airway inflammation (Fraction of Exhaled Nitric Oxide, FENO) was investigated as a risk factor for respiratory disease, and collaboration was established with international consortia to identify genes related to respiratory and cardiovascular diseases. An update of registry information on cohort members from hospitals, general practitioners and pharmacies provides a wide spectrum of incident diagnoses and treatments between 2001 and 2014. A recently completed longitudinal follow-up of the baseline cohort will provide a further measurement point to describe changing cardiovascular risk factors in south-west Sweden. Participation at baseline was 42%, and 61% of these participated at the follow-up.

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