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The Swedish CArdioPulmonary BioImage Study: objectives and design.

Journal article
Authors Göran Bergström
G Berglund
A. Blomberg
John Brandberg
Gustav Engström
J Engvall
Marica Ericson
U de Faire
Agneta Flinck
M G Hansson
B Hedblad
Ola Hjelmgren
Carl-Erik Janson
T Jernberg
Åse (Allansdotter) Johnsson
L Johansson
L Lind
C-G Löfdahl
O Melander
C J Östgren
A Persson
M Persson
A Sandström
Caroline Schmidt
S Söderberg
J Sundström
Kjell Torén
Ann-Charlotte Waldenström
Hans Wedel
Jenny Vikgren
Björn Fagerberg
Annika Rosengren
Published in Journal of internal medicine
Volume 278
Issue 6
Pages 645–659
ISSN 1365-2796
Publication year 2015
Published at Institute of Medicine, Department of Public Health and Community Medicine, Section of Occupational and environmental medicine
Institute of Medicine, Department of Molecular and Clinical Medicine
Institute of Clinical Sciences, Section for Oncology, Radiation Physics, Radiology and Urology, Department of Radiology
Pages 645–659
Language en
Links dx.doi.org/10.1111/joim.12384
Subject categories Radiology

Abstract

Cardiopulmonary diseases are major causes of death worldwide, but currently recommended strategies for diagnosis and prevention may be outdated because of recent changes in risk factor patterns. The Swedish CArdioPulmonarybioImage Study (SCAPIS) combines the use of new imaging technologies, advances in large-scale 'omics' and epidemiological analyses to extensively characterize a Swedish cohort of 30 000 men and women aged between 50 and 64 years. The information obtained will be used to improve risk prediction of cardiopulmonary diseases and optimize the ability to study disease mechanisms. A comprehensive pilot study in 1111 individuals, which was completed in 2012, demonstrated the feasibility and financial and ethical consequences of SCAPIS. Recruitment to the national, multicentre study has recently started.

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