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Obesity alters gut microbial ecology

Scientific journal article - peer reviewed
Authors R. E. Ley
Fredrik Bäckhed
P. Turnbaugh
C. A. Lozupone
R. D. Knight
J. I. Gordon
Published in Proc Natl Acad Sci U S A
Volume 102
Issue 31
Pages 11070-11075
Publication year 2005
Published at Wallenberg Laboratory
Pages 11070-11075
Keywords Animals, Bacteria/classification/genetics/isolation & purification, Base Sequence, Cyanobacteria/classification/genetics/isolation & purification, DNA/genetics, Ecosystem, Female, Genes, Bacterial, Humans, Intestines/*microbiology, Mice, Mice, Inbred C57BL, Mice, Obese, Molecular Sequence Data, Obesity/etiology/*microbiology, Pregnancy, RNA, Ribosomal, 16S/genetics, Research Support, N.I.H., Extramural, Research Support, Non-U.S. Gov't, Research Support, U.S. Gov't, P.H.S.
Subject categories Microbiology in the medical area

Abstract

We have analyzed 5,088 bacterial 16S rRNA gene sequences from the distal intestinal (cecal) microbiota of genetically obese ob/ob mice, lean ob/+ and wild-type siblings, and their ob/+ mothers, all fed the same polysaccharide-rich diet. Although the majority of mouse gut species are unique, the mouse and human microbiota(s) are similar at the division (superkingdom) level, with Firmicutes and Bacteroidetes dominating. Microbial-community composition is inherited from mothers. However, compared with lean mice and regardless of kinship, ob/ob animals have a 50% reduction in the abundance of Bacteroidetes and a proportional increase in Firmicutes. These changes, which are division-wide, indicate that, in this model, obesity affects the diversity of the gut microbiota and suggest that intentional manipulation of community structure may be useful for regulating energy balance in obese individuals. The sequences reported in this paper have been deposited in the GenBank database [accession nos. DQ 014552--DQ 015671 (mothers) and AY 989911--AY 993908 (offspring)].

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