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- Lena Björkman
Lena Björkman
Adjunct Senior Lecturer
Department of Rheumatology and Inflammation-
Larixol is not an inhibitor of Gα<inf>i</inf> containing G proteins and lacks effect on signaling mediated by human neutrophil expressed formyl peptide
receptors
Lena Björkman, Huamei Forsman, Linda Bergqvist, Claes Dahlgren, Martina Sundqvist
Biochemical Pharmacology - 2024 -
Function and regulation of GPR84 in human
neutrophils
Huamei Forsman, Claes Dahlgren, Jonas Mårtensson, Lena Björkman, Martina Sundqvist
British Journal of Pharmacology - 2023 -
The ketone body acetoacetate activates human neutrophils through
FFAR2.
Jonas Mårtensson, Lena Björkman, Simon Lind, Moa Viklund, Linjie Zhang, Saray Gutierrez, Claes Dahlgren, Martina Sundqvist, Xin Xie, Huamei Forsman
Journal of leukocyte biology - 2023 -
AZ2158 is a more potent formyl peptide receptor 1 inhibitor than the commonly used peptide antagonists in abolishing neutrophil
chemotaxis.
Huamei Forsman, Yanling Wu, Jonas Mårtensson, Lena Björkman, Kenneth L Granberg, Claes Dahlgren, Martina Sundqvist
Biochemical pharmacology - 2023 -
Severe chronic non-bacterial osteomyelitis in combination with total MPO deficiency and responsiveness to TNFα
inhibition
Martina Sundqvist, Karin Christenson, Per Wekell, Halla Björnsdottir, Agnes Dahlstrand Rudin, Felix Peter Sanchez Klose, Tilmann Kallinich, Amanda Welin, Lena Björkman, Johan Bylund, Anna Karlsson, Stefan Berg
Frontiers in Immunology - 2023 -
Genome-wide investigation of persistence with methotrexate treatment in early rheumatoid
arthritis
A. O. Sysojev, S. Saevarsdottir, L. M. Diaz-Gallo, G. N. Silberberg, L. Alfredsson, L. Klareskog, E. Baecklund, Lena Björkman, A. Kastbom, S. Rantapaa-Dahlqvist, C. Turesson, I. Jonsdottir, K. Stefansson, T. Frisell, L. Padyukov, J. Askling, H. Westerlind
Rheumatology - 2023 -
G protein coupled pattern recognition receptors expressed in neutrophils: Recognition, activation/modulation, signaling and receptor regulated
functions.
Claes Dahlgren, Simon Lind, Jonas Mårtensson, Lena Björkman, Yanling Wu, Martina Sundqvist, Huamei Forsman
Immunological reviews - 2022 -
Multiomics analysis of rheumatoid arthritis yields sequence variants that have large effects on risk of the seropositive
subset
S. Saevarsdottir, L. Stefansdottir, P. Sulem, G. Thorleifsson, E. Ferkingstad, G. Rutsdottir, B. Glintborg, H. Westerlind, G. Grondal, I. C. Loft, S. B. Sorensen, B. A. Lie, M. Brink, L. Arlestig, A. O. Arnthorsson, E. Baecklund, K. Banasik, S. Bank, Lena Björkman, T. Ellingsen, C. Erikstrup, O. Frei, Inger Gjertsson, D. F. Gudbjartsson, S. A. Gudjonsson, G. H. Halldorsson, O. Hendricks, J. Hillert, E. Hogdall, S. Jacobsen, D. V. Jensen, H. Jonsson, A. Kastbom, I. Kockum, S. Kristensen, H. Kristjansdottir, M. H. Larsen, A. Linauskas, E. M. Hauge, A. G. Loft, B. R. Ludviksson, S. H. Lund, T. Markusson, G. Masson, P. Melsted, K. H. S. Moore, H. Munk, K. R. Nielsen, G. L. Norddahl, A. Oddsson, T. A. Olafsdottir, P. I. Olason, T. Olsson, S. R. Ostrowski, K. Horslev-Petersen, S. Rognvaldsson, H. Sanner, G. N. Silberberg, H. Stefansson, E. Sorensen, I. J. Sorensen, C. Turesson, T. Bergman, L. Alfredsson, T. K. Kvien, S. Brunak, K. Steinsson, V. Andersen, O. A. Andreassen, S. Rantapaa-Dahlqvist, M. L. Hetland, L. Klareskog, J. Askling, L. Padyukov, O. B. Pedersen, U. Thorsteinsdottir, I. Jonsdottir, K. Stefansson
Annals of the Rheumatic Diseases - 2022 -
GRK2 selectively attenuates the neutrophil NADPH-oxidase response triggered by beta-arrestin recruiting GPR84
agonists
Johanna Fredriksson, André Holdfeldt, Jonas Mårtensson, Lena Björkman, T. C. Moller, E. Mullers, Claes Dahlgren, Martina Sundqvist, Huamei Forsman
Biochimica Et Biophysica Acta-Molecular Cell Research - 2022 -
The Two Formyl Peptide Receptors Differently Regulate GPR84-Mediated Neutrophil NADPH Oxidase
Activity
Jonas Mårtensson, Martina Sundqvist, A. Manandhar, L. Leremias, L. J. Zhang, T. Ulven, X. Xie, Lena Björkman, Huamei Forsman
Journal of Innate Immunity - 2021 -
The neutrophil subset defined by CD177 expression is preferentially recruited to gingival crevicular fluid in
periodontitis.
Agnes Dahlstrand Rudin, Firoozeh Amirbeagi, Lisa Davidsson, Arsham Khamzeh, Sara Thorbert Mros, Pontus Thulin, Amanda Welin, Lena Björkman, Karin Christenson, Johan Bylund
Journal of leukocyte biology - 2021 -
Neutrophil Signaling That Challenges Dogmata of G Protein-Coupled Receptor Regulated
Functions
Claes Dahlgren, André Holdfeldt, Simon Lind, Jonas Mårtensson, Michael Gabl, Lena Björkman, Martina Sundqvist, Huamei Forsman
ACS Pharmacology and Translational Science - 2020 -
Increased CD11b and Decreased CD62L in Blood and Airway Neutrophils from Long-Term Smokers with and without
COPD.
Marit Stockfelt, Karin Christenson, Anders Andersson, Lena Björkman, Médea Padra, Bettina Brundin, Koustav Ganguly, Helga Asgeirsdottir, Sara K. Lindén, Ingemar Qvarfordt, Johan Bylund, Anders Lindén
Journal of Innate Immunity - 2020 -
In Vivo Transmigrated Human Neutrophils Are Highly Primed for Intracellular Radical Production Induced by Monosodium Urate
Crystals.
Lisa Davidsson, Agnes Dahlstrand Rudin, Felix Peter Sanchez Klose, Alicia Buck, Lena Björkman, Karin Christenson, Johan Bylund
International journal of molecular sciences - 2020 -
Cathepsin g Degrades Both Glycosylated and Unglycosylated Regions of Lubricin, a Synovial
Mucin
Shan Huang, Kristina A Thomsson, Chunsheng Jin, Sally Alweddi, A. Struglics, Ola Rolfson, Lena Björkman, S. Kalamajski, T. A. Schmidt, G. D. Jay, R. Krawetz, Niclas G. Karlsson, T. Eisler
Scientific Reports - 2020 -
Decrease of core 2 O-glycans on synovial lubricin in osteoarthritis reduces galectin-3 mediated
crosslinking.
Sarah A. Flowers, Kristina A Thomsson, Liaqat Ali, Shan Huang, Yolanda H. Mthembu, Suresh C Regmi, Jan Holgersson, Tannin A Schmidt, Ola Rolfson, Lena Björkman, Martina Sundqvist, Anna Karlsson-Bengtsson, Gregory D Jay, Thomas Eisler, Roman Krawetz, Niclas G. Karlsson
The Journal of biological chemistry - 2020 -
Interdependent allosteric free fatty acid receptor 2 modulators synergistically induce functional selective activation and desensitization in
neutrophils
Simon Lind, André Holdfeldt, Jonas Mårtensson, Martina Sundqvist, T. P. Kenakin, Lena Björkman, Huamei Forsman, Claes Dahlgren
Biochimica Et Biophysica Acta-Molecular Cell Research - 2020 -
Functional selective ATP receptor signaling controlled by the free fatty acid receptor 2 through a novel allosteric modulation
mechanism.
Simon Lind, André Holdfeldt, Jonas Mårtensson, Martina Sundqvist, Lena Björkman, Huamei Forsman, Claes Dahlgren
FASEB journal : official publication of the Federation of American Societies for Experimental Biology - 2019 -
Functional characteristics of circulating granulocytes in severe congenital neutropenia caused by ELANE
mutations
Q. Liu, Martina Sundqvist, W. Y. Li, André Holdfeldt, L. Zhang, Lena Björkman, Johan Bylund, Claes Dahlgren, C. Wang, X. D. Zhao, Huamei Forsman
Bmc Pediatrics - 2019 -
Neutrophil recruitment to inflamed joints can occur without cellular
priming.
Lena Björkman, Karin Christenson, Lisa Davidsson, Jonas Mårtensson, Firoozeh Amirbeagi, Amanda Welin, Huamei Forsman, Anna Karlsson, Claes Dahlgren, Johan Bylund
Journal of leukocyte biology - 2019 -
Neutrophil priming that turns natural FFA2R agonists into potent activators of the superoxide generating
NADPH-oxidase
Jonas Mårtensson, André Holdfeldt, Martina Sundqvist, Michael Gabl, T. P. Kenakin, Lena Björkman, Huamei Forsman, Claes Dahlgren
Journal of leukocyte biology - 2018 -
Similarities and differences between the responses induced in human phagocytes through activation of the medium chain fatty acid receptor GPR84 and the short chain fatty acid receptor
FFA2R.
Martina Sundqvist, Karin Christenson, André Holdfeldt, Michael Gabl, Jonas Mårtensson, Lena Björkman, Regis Dieckmann, Claes Dahlgren, Huamei Forsman
Biochimica et biophysica acta - 2018 -
Incidence of and risk factors for nephrolithiasis in patients with gout and the general population, a cohort
study
Anton J. Landgren, Lennart T. H. Jacobsson, Ulf Lindström, Tatiana Zverkova Sandström, Panagiota Drivelegka, Lena Björkman, E. Fjellstedt, Mats Dehlin
Arthritis Research & Therapy - 2017 -
Cartilage oligomeric matrix protein forms protein complexes with synovial lubricin via non-covalent and covalent
interactions
Sarah A. Flowers, S. Kalamajski, Lena Björkman, A. Aspberg, Niclas G. Karlsson, C Jin
Osteoarthritis and Cartilage - 2017 -
Androgens in women after allogeneic hematopoietic cell transplantation: impact of chronic GvHD and glucocorticoid
therapy.
Yvonne Björk, Eva Smith Knutsson, Carina Ankarberg-Lindgren, A-K Broman, I. Andersson, Lena Björkman, J Magnusson, Karin Bergmark, H Anderson, P-O Andersson, Mats Brune
Bone marrow transplantation - 2017 -
Lubricin binds cartilage proteins, cartilage oligomeric matrix protein, fibronectin and collagen II at the cartilage
surface
Sarah A. Flowers, A. Zieba, Jessica Örnros, Chunsheng Jin, Ola Rolfson, Lena Björkman, T. Eisler, S. Kalamajski, M. Kamali-Moghaddam, Niclas G. Karlsson
Scientific Reports - 2017 -
Data on the NADPH-oxidase activity induced by WKYMVm and galectin-3 in bone marrow derived and exudated neutrophils isolated from four different mouse
strains.
Lena Björkman, Huamei Forsman, Karin Önnheim
Data in brief - 2017 -
The Neutrophil Response Induced by an Agonist for Free Fatty Acid Receptor 2 (GPR43) Is Primed by Tumor Necrosis Factor Alpha and by Receptor Uncoupling from the Cytoskeleton but Attenuated by Tissue
Recruitment
Lena Björkman, Jonas Martensson, Malene Winther, Michael Gabl, André Holdfeldt, Martin Uhrbom, Johan Bylund, A. H. Hansen, S. K. Pandey, T. Ulven, Huamei Forsman, Claes Dahlgren
Molecular and Cellular Biology - 2016 -
Neutrophils from patients with SAPHO syndrome show no signs of aberrant NADPH oxidase-dependent production of intracellular reactive oxygen
species.
Per Wekell, Halla Björnsdottir, Lena Björkman, Martina Sundqvist, Karin Christenson, Veronica Osla, Stefan Berg, Anders Fasth, Amanda Welin, Johan Bylund, Anna Karlsson
Rheumatology (Oxford, England) - 2016 -
Collection of in vivo transmigrated neutrophils from human
skin.
Karin Christenson, Lena Björkman, Lisa Davidsson, Anna Karlsson, Per Follin, Claes Dahlgren, Johan Bylund
Methods in molecular biology (Clifton, N.J.) - 2014 -
Neutrophils produce interleukin-17B in rheumatoid synovial
tissue
V. P. Kouri, J. Olkkonen, M. Ainola, T. F. Li, Lena Björkman, Y. T. Konttinen, J. Mandelin
Rheumatology - 2014 -
Endogenous Acute Phase Serum Amyloid A Lacks Pro-Inflammatory Activity, Contrasting the Two Recombinant Variants That Activate Human Neutrophils through Different
Receptors.
Karin Christenson, Lena Björkman, Sofie Ahlin, Maja Olsson, Kajsa Sjöholm, Anna Karlsson, Johan Bylund
Frontiers in immunology - 2013 -
A simple skin blister technique for the study of in vivo transmigration of human
leukocytes.
Lisa Davidsson, Lena Björkman, Karin Christenson, Mikael Alsterholm, Charlotta Movitz, Fredrik Bergh Thorén, Anna Karlsson, Amanda Welin, Johan Bylund
Journal of immunological methods - 2013 -
The Human Neutrophil Subsets Defined by the Presence or Absence of OLFM4 Both Transmigrate into Tissue In Vivo and Give Rise to Distinct NETs In
Vitro.
Amanda Welin, Firoozeh Amirbeagi, Karin Christenson, Lena Björkman, Halla Björnsdottir, Huamei Forsman, Claes Dahlgren, Anna Karlsson, Johan Bylund
PloS one - 2013 -
Regulation of Neutrophil Apoptosis Differs after in vivo Transmigration to Skin Chambers and Synovial Fluid: A Role for Inflammasome-Dependent Interleukin-1 beta
Release
Karin Christenson, Lena Björkman, Anna Karlsson, Johan Bylund
Journal of Innate Immunity - 2013 -
Human Synovial Lubricin Expresses Sialyl Lewis x Determinant and Has L-selectin Ligand
Activity
Chunsheng Jin, Anna-Karin H Ekwall, Johan Bylund, Lena Björkman, R. P. Estrella, J. M. Whitelock, T. Eisler, Maria Bokarewa, Niclas G. Karlsson
Journal of Biological Chemistry - 2012 -
In vivo-transmigrated human neutrophils are resistant to antiapoptotic
stimulation.
Karin Christenson, Lena Björkman, Jennie Karlsson, Martina Sundqvist, Charlotta Movitz, David P Speert, Claes Dahlgren, Johan Bylund
Journal of leukocyte biology - 2011 -
A methodological approach to studies of desensitization of the formyl peptide receptor: Role of the read out system, reactive oxygen species and the specific agonist used to trigger
neutrophils.
Jennie Karlsson, Johan Bylund, Charlotta Movitz, Lena Björkman, Huamei Forsman, Claes Dahlgren
Journal of immunological methods - 2010 -
The proinflammatory activity of recombinant serum amyloid A is not shared by the endogenous protein in the
circulation.
Lena Björkman, John G Raynes, Chandrabala Shah, Anna Karlsson, Claes Dahlgren, Johan Bylund
Arthritis and rheumatism - 2010 -
The Role Of Serum Amyloid A In Inflammatory Disease - Proinflammatory Mediator Or Inert
Biomarker?
Lena Björkman
2010 -
Serum amyloid A inhibits apoptosis of human neutrophils via a P2X7-sensitive pathway independent of formyl peptide receptor-like
1
Karin Christenson, Lena Björkman, Carolina Tängemo, Johan Bylund
Journal of Leukocyte Biology - 2008 -
Changes in the ratio between FPR and FPRL1 triggered superoxide production in human neutrophils-a tool in analysing receptor specific
events
Huamei Fu, Jennie Karlsson, Lena Björkman, Anna-Lena Stenfeldt, Anna Karlsson, Johan Bylund, Claes Dahlgren
Journal of Immunological Methods - 2008 -
Serum amyloid A mediates human neutrophil production of reactive oxygen species through a receptor independent of formyl peptide receptor
like-1
Lena Björkman, Jennie Karlsson, Anna Karlsson, M. J. Rabiet, F. Boulay, Huamei Fu, Johan Bylund, Claes Dahlgren
Journal of Leukocyte Biology - 2008 -
Phagocyte-derived reactive oxygen species as suppressors of inflammatory
disease
Lena Björkman, Claes Dahlgren, Anna Karlsson, Kelly Brown, Johan Bylund
Arthritis & Rheumatism - 2008 -
The two neutrophil members of the formylpeptide receptor family activate the NADPH-oxidase through signals that differ in sensitivity to a gelsolin derived phosphoinositide-binding
peptide
Huamei Fu, Lena Björkman, P. Janmey, Anna Karlsson, Jennie Karlsson, Charlotta Movitz, Claes Dahlgren
BMC cell biology - 2004