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OPEN POSITIONS PhD position in Medical Science - Inflammation and brain injury in the newborn

Project title:Role of inflammation-induced metabolic reprogramming of microglia in perinatal brain injury

Job assignments

General information about third-cycle studies: The PhD education in Medical Science corresponds to studies of 240 credits in total. The studies are equivalent to four year full-time and lead to a Degree of Doctor. The studies comprise carrying out a scientific project and completing at least 30 credits of courses at third-cycle level. The doctoral student must also write a scientific compilation thesis or monograph corresponding to at least 120 credits. For more information about third-cycle studies at Sahlgrenska Academy, see http://sahlgrenska.gu.se/english/doctoral-student-portal/from-admission-to-defending-your-thesis/phd-subjects/

Project: Inflammation has emerged as a common driving force in the development of brain injury in newborn infants, a condition strongly associated with developmental impairment and neurological deficits. The most common infection in late onset neonatal sepsis is coagulase-negative staphylococci, such as Staphylococcus epidermidis. A novel concept in immunology is that a family of innate immune receptors, so called Toll-Like Receptors, are important in bacteria-induced inflammatory processes via “metabolic reprogramming” of immune cells. Staphylococcus epidermidis bacteria express soluble factors, including lipopeptides, which activate host responses via Toll-like receptor 2. Their role in the pathogenesis of inflammation-induced brain injury remains largely unknown. The Hypothesis of this project is that systemic inflammation leads to activation of toll-like receptor activation, which results in immune reactions in the brain, depressed mitochondrial energy metabolism and increased vulnerability to brain injury. We suggest that sirtuins (class III histone deacetylases) are key mediators of these effects and provide a novel potential target for neuroprotection. We will investigate how this clinically relevant infection affect brain inflammation, metabolic energetics and brain injury. Further, novel neuroprotective strategies will be employed.

The PhD project consists of 3 sub-projects, with the specific aims:
- Effects of Staphylococcus epidermidis infection on energy metabolism (oxidative phosphorylation, glycolysis) and sirtuin activity in brain immune cells - microglia
- The role of a clinically relevant infection, Staphylococcus epidermidis, in neonatal brain injury
- Sirtuins as a novel target in perinatal brain injury

The PhD student will join an interactive group including both clinical and pre-clinical scientists. The project will provide the PhD student with a range of methodological techniques including: in vitro murine microglia cultures, Staphylococcus epidermidis bacteria, metabolic analysis, mitochondria respiration analysis, multiplex Elisa, qPCR, flow cytometry and in vivo surgery in wild type and transgenic animals.

Eligibility

To be eligible for third-cycle studies, the applicant must meet both the general and specific entry requirements.

A person meets the general entry requirements for third-cycle studies if he or she:
1. has been awarded a second-cycle qualification
2. has satisfied the requirements for courses comprising at least 240 credits of which at least 60 credits were awarded in the second-cycle, or
3. has acquired substantially equivalent knowledge in some other way in Sweden or abroad

A person meets the specific entry requirements for third-cycle studies if he or she: has successfully completed the English B/6 course or is considered to have acquired equivalent knowledge through previous studies

Assessment

In selecting between applicants who meet the general and specific entry requirements, their ability to benefit from third-cycle studies shall be taken into account. The assessment shall attach particular importance to documented qualifications for:
- specific knowledge and skills within the subject area and related research fields
- experience of scientific theory and relevant research methodology
- scientific analysis and presentation verified through thesis, degree project, scientific journals or the like.

Employment

Time limited employment (temporary), 4 years. Extent: 100%. Location: Sahlgrenska Academy, Institute of Neuroscience and Physiology, Department of Physiology. First day of employment: as agreed.

Regulations for employment of doctoral students are given in SFS 1998:80. Only those who are admitted to third-cycle studies may be appointed to doctoral studentships. Those appointed to doctoral studentships shall primarily devote themselves to their studies. They may, however, work to a limited extent with educational tasks, research and administration according to the regulations.

The initial appointment may apply for no longer than one year. An appointment may be renewed for no more than two years at a time. The total employment period may not exceed the time corresponding to full-time third-cycle studies for four years.

Salaries for doctoral students are regulated in a local agreement at the University.

For further information regarding the position

For more information about the project please contact the project supervisor, Carina Mallard, carina.mallard@neuro.gu.se

For more information regarding PhD education at Sahlgrenska Academy visit http://sahlgrenska.gu.se/english/doctoral-student-portal/

Unions

Union representatives at the University of Gothenburg: http://www.gu.se/english/about_the_university/job-opportunities/union-representatives

How to apply

In order to apply for a position at the University of Gothenburg, you have to register an account in our online recruitment system. Attach verified copies of your education and English proficiency proving your eligibility. It is the responsibility of the applicant to ensure that the application is complete in accordance with the instructions in the job advertisement, and that it is submitted before the deadline. The selection of candidates is made on the basis of the qualifications registered in the application.

Closing date 2017-11-22

The University of Gothenburg promotes equal opportunities, equality and diversity.

Applications will be destroyed or returned (upon request) two years after the decision of employment has become final. Applications from the employed and from those who appeal the decision will not be returned.

The University of Gothenburg tackles society’s challenges with diverse knowledge. 38 000 students and 6 000 employees make the university a large and inspiring place to work and study. Strong research and attractive study programmes attract scientists and students from around the world. With new knowledge and new perspectives, the University contributes to a better future.

In connection to this recruitment, we have already decided which recruitment channels we should use. We therefore decline further contact with vendors, recruitment and staffing companies.

Page Manager: rekrytering@gu.se|Last update: 2/23/2017
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