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OPEN POSITIONS PhD position in Medical Science - Eosinophilic esophagitis & suppressive eosinophils

Project title: Is eosinophilic esophagitis due to a lack of suppressive eosinophils?

Job assignments

General information about third-cycle studies: The PhD education in Medical Science corresponds to studies of 240 credits in total. The studies are equivalent to four year full-time and lead to a Degree of Doctor. The studies comprise carrying out a scientific project and completing at least 30 credits of courses at third-cycle level. The doctoral student must also write a scientific compilation thesis or monograph corresponding to at least 120 credits. For more information about third-cycle studies at Sahlgrenska Academy, see http://sahlgrenska.gu.se/english/doctoral-student-portal/from-admission-to-defending-your-thesis/phd-subjects/

Project
Background: Eosinophilic esophagitis is a new disease that is considered to be a variant of food allergy. The condition affects children and adults alike and causes inflammation of the esophagus with feeding difficulties. The diagnosis is based on typical symptoms and the finding of elevated levels of eosinophilic granulocytes in biopsies collected from the esophagus. The disease is chronic and treated by avoidance of food allergens and corticosteroids. Eosinophilic granulocytes have the ability to regulate the function of lymphocytes. We have identified a subset of eosinophils capable of regulating the activity of T cells, which we have named "suppressive eosinophils". Patients with untreated eosinophilic esophagitis appear to have low numbers of suppressive eosinophils in the blood. Our hypothesis is that the eosinophils from patients with eosinophilic esophagitis have impaired capacity to regulate the T cells that drive this disease.

Aims: To understand the role of eosinophils in eosinophilic esophagitis with focus on their capacity to regulate T cell activity. To increase the knowledge regarding the immunopathogenesis of eosinophilic esophagitis.

Project description: The PhD student will be part of an exciting translational research project and become familiar with the entire project lay-out from the planning of studies, ethical permission applications, recruitment of patients, logistics regarding collection of blood and tissue samples, challenges of interpreting validated questionnaires for assessment of symptoms and quality of life, and the importance of good collaboration with hospital employees and scientists. The main focus of the project is on experimental research. The student will learn how to master a number of laboratory methods for cellular immunology studies and imaging techniques. An important objective is for the student to learn how to interpret results, assess strengths and weaknesses of various methods, and handle data sets including doing statistical analyses. The student will also receive training regarding how to present results orally and in written form, and how to analyze his/her results in relation to the results of other scientists.

Eligibility

To be eligible for third-cycle studies, the applicant must meet both the general and specific entry requirements.

A person meets the general entry requirements for third-cycle studies if he or she:
1. has been awarded a second-cycle qualification
2. has satisfied the requirements for courses comprising at least 240 credits of which at least 60 credits were awarded in the second-cycle, or
3. has acquired substantially equivalent knowledge in some other way in Sweden or abroad

A person meets the specific entry requirements for third-cycle studies if he or she: has successfully completed the English B/6 course or is considered to have acquired equivalent knowledge through previous studies

Assessment

In selecting between applicants who meet the general and specific entry requirements, their ability to benefit from third-cycle studies shall be taken into account. The assessment shall attach particular importance to documented qualifications for:
- specific knowledge and skills within the subject area and related research fields
- experience of scientific theory and relevant research methodology
- scientific analysis and presentation verified through thesis, degree project, scientific journals or the like.

Employment

Time limited employment (temporary), 4 years. Extent: 100%. Location: Sahlgrenska Academy, Institute of Biomedicine, Department of Infectious Diseases. First day of employment: as agreed.

Regulations for employment of doctoral students are given in SFS 1998:80. Only those who are admitted to third-cycle studies may be appointed to doctoral studentships. Those appointed to doctoral studentships shall primarily devote themselves to their studies. They may, however, work to a limited extent with educational tasks, research and administration according to the regulations.

The initial appointment may apply for no longer than one year. An appointment may be renewed for no more than two years at a time. The total employment period may not exceed the time corresponding to full-time third-cycle studies for four years.

Salaries for doctoral students are regulated in a local agreement at the University.

For further information regarding the position

For more information about the project please contact the project supervisor, Christine Wennerås, christine.wenneras@microbio.gu.se

For more information regarding PhD education at Sahlgrenska Academy visit http://sahlgrenska.gu.se/english/doctoral-student-portal/

Unions

Union representatives at the University of Gothenburg: http://www.gu.se/english/about_the_university/job-opportunities/union-representatives

How to apply

In order to apply for a position at the University of Gothenburg, you have to register an account in our online recruitment system. Attach verified copies of your education and English proficiency proving your eligibility. It is the responsibility of the applicant to ensure that the application is complete in accordance with the instructions in the job advertisement, and that it is submitted before the deadline. The selection of candidates is made on the basis of the qualifications registered in the application.

Closing date 2017-11-22

The University of Gothenburg promotes equal opportunities, equality and diversity.

Applications will be destroyed or returned (upon request) two years after the decision of employment has become final. Applications from the employed and from those who appeal the decision will not be returned.

The University of Gothenburg tackles society’s challenges with diverse knowledge. 38 000 students and 6 000 employees make the university a large and inspiring place to work and study. Strong research and attractive study programmes attract scientists and students from around the world. With new knowledge and new perspectives, the University contributes to a better future.

In connection to this recruitment, we have already decided which recruitment channels we should use. We therefore decline further contact with vendors, recruitment and staffing companies.

Page Manager: rekrytering@gu.se|Last update: 2/23/2017
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