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PhD student in Microbiology: Cell Biology of Metal Toxicity

Type of employment: Fixed-term employment, 4 years
Extent: 100 %
Location: Department of Chemistry and Molecular Biology, Gothenburg
First day of employment: April 1 2016
Reference number: UR 2016/121

Research and graduate education at the department of chemistry and molecular biology comprises a wide scientific field from the atomic and molecular levels all the way through cells to intact organisms. Much of the phenomena studied here impact on our natural environment and living systems. We participate in undergraduate programs in chemistry, molecular biology, medicinal chemistry, biology, marine sciences, and pharmacy.
A third cycle education at our department will lead to a Ph.D. in Natural sciences, natural sciences with a specialisation in Chemistry or natural sciences with a specialisation in biology. Ph.D studies comprises four years at the post graduate level. The time period can be extended to 5 years in total through teaching and/or other departmental duties.

Molecular biology of metal toxicity and tolerance

Many metals endanger the environment and human health, but are also increasingly used as therapeutic agents for medical treatment. Yet, little is known about the molecular mechanisms causing metal toxicity or the mechanisms by which eukaryotic cells counteract toxicity and acquire tolerance.
To gain insights into metal action and cellular tolerance mechanisms, we use front-line tools in molecular biology, biochemistry, cell biology, chemical biology and functional genomics. We study (1) transport proteins through which metals enter or leave cells, (2) signal transduction and transcriptional regulatory mechanisms that cells use to sense and respond to metals, and (3) proteins and cellular processes that are targeted by metals. We use the model eukaryote Saccharomyces cerevisiae to explore fundamental aspects of metal biology and also as a heterologous expression system to study tolerance factors from other organisms such as plants and mammals.
For more information: http://cmb.gu.se/english/about_us/staff?&userId=xtamma

Job assignments

This PhD project, funded by Formas, aims at advancing our molecular understanding of the toxicity and biological actions of selected metals that are now emerging as environmental contaminants. The PhD student will also identify molecular markers that can serve as warning flags of metal exposure. For this, genome-wide approaches will be used with yeast as toxicological model.

The PhD student will be exposed to a broad range of scientific tasks and research questions that require a genuine interest in and knowledge of microbiology and molecular biology. Methods in microbiology, molecular biology, cell biology, functional genomics and biochemistry will be used.

Eligibility

The qualifications for education on a doctoral level are: degree in advanced level, at least 240 university points, of which 60 are on an advanced level, or in an other way acquired similar knowledge.

Assessment

Regulations for the evaluation of qualifications for education on a doctoral level are given in SFS 1998:80.

We seek a talented and dedicated student eager to pursue a career in microbiology/molecular biology. You should be open-minded, eager to learn and have a genuine interest in Science. You should be able to work independently and in a team and communicate well in English. The ideal candidate has an educational background in microbiology/molecular biology and practical experience with experimental techniques in microbiology, molecular biology, cell biology, functional genomics and/or biochemistry. Documented experience with such techniques and experience with yeast as model system is considered an advantage.

Related information

For further information please contact

Göran Hilmersson, Head of Department
+46 31 786 9022
hilmers@chem.gu.se

Markus Tamas, Professor
+46 31 786 2548
markus.tamas@cmb.gu.se

www.cmb.gu.se

Closing date

2016-02-29

Appointment Procedure

Please apply online

The application shall include:
- Cover letter with an explanation of why you apply for the position
- CV including scientific publications
- Copy of exam certificate
- Two referees (name, telephone no, relation)

Complementary documents, such as publications/books should be sent to the following address:

Department of Chemistry and Molecular Biology
Helena Bergkvist
University of Gothenburg
Box 462
405 30 Göteborg

Reference number should be clearly stated when sending complementary documents.



The University of Gothenburg promotes equal opportunities, equality and diversity.

Applications will be destroyed or returned (upon request) two years after the decision of employment has become final. Applications from the employed and from those who appeal the decision will not be returned.

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Page Manager: rekrytering@gu.se|Last update: 8/22/2016

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